9 nirs in the setting of cerebral ischemia
A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 1 ppsx
Ngày tải lên :
14/08/2014, 07:20
... determined by the objectives of the study and not the other way around Begin by printing out a copy of the final report(s) you would like to see: A Manager’s Guide to the Design and Conduct of Clinical ... already taking an anticoagulant, an aspirin could mean death On the back of the aspirin bottle, in large bold print, much larger than the other writing you’ll find on the label, are the words, ... cases, retrospective studies of the effects of the intervention in humans The focus of this text is the final or Phase III clinical trial These involve large numbers of subjects (500 to 5000), studied...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 2 pps
Ngày tải lên :
14/08/2014, 07:20
... why the group was from the very beginning of the falling behind They’d doubled the number of testers, yet there process In the final stages of testing, was no corresponding increase the clinical ... changes in a primary or secondary end point will rule in favor of the null hypothesis and which in favor of the alternative needs to be made in advance of the trials for each of the end points Nothing ... ensure the safety of the participants in the trials Their secondary responsibility is to ensure the integrity of the trials: the investigators, the regulatory agency, and the sponsor will rely on their...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 3 pps
Ngày tải lên :
14/08/2014, 07:20
... referred to as triple blinding in that neither the patient, the treating physician, nor the examining physician is aware of the treatment the patient receives In comparisons of surgical procedures ... or on the basis of some other important cofactor, then you will want to randomize separately within each of the distinct groups The rationale is exactly the same as discussed in the preceding section: ... data, they found that of 730 patients randomized to the active therapy, 56 died, while of the BEWARE OF HOLES IN THE INSTRUCTIONS The instructions for Bumbling Pharmaceutical’s latest set of trials...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 4 potx
Ngày tải lên :
14/08/2014, 07:20
... description of the experimental design, including the extent of the blinding and the method(s) to be employed to ensure the blinding is sustained throughout the course of the trials Sample size Method of ... tablet, ointment) Route of administration (oral, intramuscular, intravenous) Frequency of administration For intravenous administration include the rate of administration and the concentration of the ... pertinent endpoints, or on use in combination therapy) • Provide an evaluation of benefits and risks based upon the conclusions of the relevant clinical studies, including interpretation of how the efficacy...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 5 potx
Ngày tải lên :
14/08/2014, 07:20
... during the design process and only the numbers remain to be filled in during the analysis phase It is our reports that should determine the nature of the data we collect By preparing the form of ... prominent medical journals such as The Lancet, Annals of Internal Medicine, and the Journal of the American Medical Association Its use is the guarantee of integrity in the reported results of ... readers with a clear picture of the progress of all participants in the trial, from the time they are randomized until the end of their involvement The intent is to make the experimental process...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 6 pdf
Ngày tải lên :
14/08/2014, 07:20
... entering the data Thus she needs to be thoroughly familiar with the data entry process before training begins The training can be accomplished either in individual or in group training sessions The ... be the responsibility of a single developer working in tandem with a single CRM Between them they will work out the context and sequencing of the screens needed to record their portion of the ... LEN DATA TYPE EXPLANATION (none) 20 Text The ID of the site INVID (none) 20 Text No INVNAM (none) 80 Text The ID of the investigator The name of the investigator Cond SCRNNUM (none) 20 Text No...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 7 pot
Ngày tải lên :
14/08/2014, 07:20
... divide the data up? A good rule of thumb is to combine all the information collected by a single individual at a single point of time in the same file We link the disparate files with the aid of keys ... physician interest throughout lengthy trials The medical monitor should write out the responsibilities of the clinical investigator, provide training in these responsibilities, remind investigators of ... each investigator The purpose of these meetings is threefold: To survey the investigator’s working arrangements To establish rapport with and gain the trust of the investigator To arrange for the...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 8 pot
Ngày tải lên :
14/08/2014, 07:20
... expect the sample mean to lie within two standard errors of the mean of our original sample Increasing the sample size decreases the standard error, reflecting the increase in precision of the mean ... compromising the integrity of the trials The only “cost” is several more days of the statistician’s time and several minutes of the computer’s At issue in some instances is whether individuals ... modifying, terminating, or extending trials in progress We consider the functions of the first two types of committee in this section and of the latter trial review and safety committee in the following...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 9 doc
Ngày tải lên :
14/08/2014, 07:20
... the confidence interval and uses these to obtain a confidence interval for the means of the original observations The drawback of the preceding method is that it relies on the assumption that the ... the FDA will always accept results of the t-test without the equal variances assumption—they would rather this than think.” Wilcoxon test The use of the ranks in the combined sample reduces the ... takes the logarithms of the observations, computes the mean and standard error of the logarithms and determines a symmetric confidence interval One then takes the antilogarithms of the boundaries of...
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A MANAGER’S GUIDE TO THE DESIGN AND CONDUCT OF CLINICAL TRIALS - PART 10 potx
Ngày tải lên :
14/08/2014, 07:20
... effective in women when used in accordance with doctor’s instructions,” and the resultant improvement in Bumbling’s bottom line But then, I was thinking from the corporation’s point of view In the ... sufficiently the importance of including representatives of all study teams, past and present, on posttrial committees Every trial results in the uncovering of information that may prove of value in collateral ... neglected? Were there baseline imbalances? How could they have been prevented? Was blinding maintained? If not, why not? Did you gather all the information you needed? What other observations...
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the first chapter will start with the introduction to the problem that mai dong mechanical company has been facing and also the research design and methodology of the research
Ngày tải lên :
14/10/2014, 01:10
... resources of trainers and coachers, the company also has saved a lot of money in conducting training needs assessment, organizing and delivering the training courses in house And also the training ... attend the training course, they underestimate the quality of training programs They find it not relevant and ineffective for their job The following survey results clearly reflect the ineffectiveness ... integration at the current They can only deliver their knowledge and working skills that they have been applying and experiencing in their works during the previous years to trainees The trainees,...
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The Design and Implementation of a Log-Structured File System
Ngày tải lên :
12/09/2012, 15:05
... because the log is the final home of the data Rather than redoing the operation to the separate data copy, Sprite LFS recovery insures that the indexes point at the newest copy of the data in the ... maintain the current location of each inode Given the identifying number for a file, the inode map must be indexed to determine the disk address of the inode The inode map is divided into blocks ... shows the relative importance of the various kinds of data written to disk, both in terms of how much of the live blocks they occupy on disk and in terms of how much of the data written to the...
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Tài liệu The Design and Performance of a Real-time CORBA Event Service doc
Ngày tải lên :
19/02/2014, 18:20
... typically involve loading the this pointer, adjustment of the this pointer (for multiple inheritance), lookup of the method offset in the virtual method table, and final calculation of the address ... events In both tests, there was no other significant activity on the workstation during the benchmarking All tests were run in the Solaris real-time scheduling class so they had the highest software ... configuration supports neither real-time dispatching nor filtering/correlations In ing Module in the context of the Event Channel The particiessence, this implements the semantics of the standard COS Event...
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Báo cáo khoa học: Functional studies of crustacean hyperglycemic hormones (CHHs) of the blue crab, Callinectes sapidus – the expression and release of CHH in eyestalk and pericardial organ in response to environmental stress pot
Ngày tải lên :
16/03/2014, 06:20
... from the surface of the PO and into branchiocardiac veins through the direct openings of anterior and posterior bars [35] Furthermore, considering the localization of PO-CHH-producing cells in the ... varicosities in trunks of the PO Cloning and sequencing of PO-CHH cDNA The first PCR of PO cDNA with a combination of a set of primers LF1 and LR1 (Table 1) produced an amplicon of 500 bp On the basis of ... decrease in CHH expression in the ES is in proportion to that of CCAP expression in the same tissue, as described in Chung et al [47], but there is no change in CCAP of TG, indicating the tissue-specific...
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The Design and Implementation of a Sequence Database System * docx
Ngày tải lên :
16/03/2014, 16:20
... The set of records over which the aggregate is computedis defined by the moving window of the OVER clause In this case ,the window spansthe last 24 hours, but in general, the bounds of the window ... being done in the final count aggregate The results for at-end areshown in Figure The performanceof NOPD is the sameas in the atstart experiment The performance of BPPD is almost the sameas in ... sequence,(2) the record width, i.e., the number of bytes in each record, (3) the density, i.e the percentageof the positions in the underlying ordering domain that are non-empty All the sequences...
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STUDIES ON THE ECOLOGY AND CONSERVATION OF BUTTERFLIES IN EUROPE: Vol. 1: General Concepts and Case Studies pptx
Ngày tải lên :
23/03/2014, 01:20
... number of individuals is increasing at the Northern boundary of the population Results show that there is an overall increase in the number of Clouded Apollo in Estonia, with 73% of all sighting ... impossible to finalise within the original time frame However, to maintain the momentum of EBIE and to link the ecological advances to conservation, we invited five of the principal authors of EBIE ... described in 1985 but has been increasing rapidly in territory and in the number of individuals Despite the fact that the Clouded Apollo is decreasing in most areas of Europe (Meglécz et al., 1999), the...
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API - 2510A - Fire-Protection Considerations for the Design and Operation of Liquefied Petroleum Gas (LPG) Storage Facilities
Ngày tải lên :
27/03/2014, 14:07
... Training 6.2.1 FireÞghting personnel should be trained in the use of the Þre-control equipment available at the site and in the use of safe tactics that will reduce their risk of injury 1 0The ... horizontal line from the point on the 7000 Btu/hr-ft2 line intersected by the imaginary vertical line from the x-axis The point on the y-axis to which this horizontal line extends is the distance ... portions of the coating for inspection; however, periodic visual inspection of the coating is required Records of vessel inspection should be maintained 4.3 Vessel Accessories, Including Relief...
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